MIA – STORY TO BE TOLD from dump fm on Vimeo.

If you like that one, check out this supplemental clip from vimeo

FACEBOOKGOOGLEMYSPACEYOUTUBE from dump fm on Vimeo.

As for now, I can tell you we will be adding more navigation features based on our Days of the Week features, as well as a few new features that will require more active participation from you our reader. Yes YOU! you reading this right now, we want you more involved with us, because you are the reason we do what we do! You can start by sending us feedback on the new layout, and checking back for further instructions. Until then, enjoy……….

Smack Nightclub
Located in Leamington Spa, England
Capacity: 600
http://www.trysmack.co.uk/

Smack Nightclub – LED Room from SW on Vimeo.

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Loyola University researchers have identified the key components of a protein called TRIM5a that destroys HIV in rhesus monkeys. The finding could lead to new TRIM5a-based treatments that would knock out HIV in humans, said senior researcher Edward M. Campbell, PhD, of Loyola University Health System. Campbell and colleagues report their findings in an article featured on the cover of the Sept. 15, 2010 issue of the journal Virology, now available online. In 2004, other researchers reported that TRIM5a protects rhesus monkeys from HIV. The TRIM5a protein first latches on to a HIV virus, then other TRIM5a proteins gang up and destroy the virus. Humans also have TRIM5a, but while the human version of TRIM5a protects against some viruses, it does not protect against HIV.

Researchers hope to turn TRIM5a into an effective therapeutic agent. But first they need to identify the components in TRIM5a that enable the protein to destroy viruses. “Scientists have been trying to develop antiviral therapies for only about 75 years,” Campbell said. “Evolution has been playing this game for millions of years, and it has identified a point of intervention that we still know very little about.”

TRIM5a consists of nearly 500 amino acid subunits. Loyola researchers have identified six 6 individual amino acids, located in a previously little-studied region of the TRIM5a protein, that are critical in the ability of the protein to inhibit viral infection. When these amino acids were altered in human cells, TRIM5a lost its ability to block HIV-1 infection. (The research was done on cell cultures; no rhesus monkeys were used in the study.)

By continuing to narrow their search, researchers hope to identify an amino acid, or combination of amino acids, that enable TRIM5a to destroy HIV. Once these critical amino acids are identified, it might be possible to genetically engineer TRIM5a to make it more effective in humans. Moreover, a better understanding of the underlying mechanism of action might enable the development of drugs that mimic TRIM5a action, Campbell said.

In their research, scientists used Loyola’s wide-field “deconvolution” microscope to observe how the amino acids they identified altered the behavior of TRIM5a. They attached fluorescent proteins to TRIM5a to, in effect, make it glow. In current studies, researchers are fluorescently labeling individual HIV viruses and measuring the microscopic interactions between HIV and TRIM5a.

More info: Loyola University Health System news

Astronomer Dimitar Sasselov and his colleagues search for Earth-like planets that may, someday, help us answer centuries-old questions about the origin and existence of biological life elsewhere (and on Earth). How many such planets have they found already? Several hundreds.

Dimitar Sasselov works on uniting the physical and life sciences in the hunt for answers to the question of how life began. Full bio and more links

via Ted

I am slowly customizing my new bike with the help of some friends from Ohio. I love it except for one thing: The massive lock that I have to use in NYC. This awesome bendable bike, however, does not need any lock.

This has to be one of the best bike inventions in the history of bike inventions. It was created by the guy in the photos, 21-yo designer—and Adam Frucci impersonator—Kevin Scott.

I know it is hard to believe, but this thing actually works and could go into production. The bike can literally bend around a lamp post. Again: The whole bike bends to lock onto itself. First, it is rigid. Then, you push a lever and it is flexible enough to tie it to a post. Rigid. Lever. Bendable. Lever. Rigid. Lever. Bendable. I am sorry, but I just can not stop marveling at this invention. [DMU via Daily Mail]

Send an email to Jesus Diaz, the author of this post, at jesus@gizmodo.com.

iPhone 4 can both record in 720p and editing on-device with mobile iMovie.

“Apple of My Eye” – an iPhone 4 film – UPDATE: Behind the scenes footage included from Michael Koerbel on Vimeo.

Ferrari have used Segway’s as a transportation method around their Maranello factory for sometime now, the Segway PT i2 Ferrari Limited Edition comes in Ferrari’s signature color, red and features the Scuderia Ferrari logo at the base. Even though it came out three years ago its still raw. It can be yours for the meager price of $12,000.

BET YA BABY DADDY AIN””””T CRAFTY LIKE THE KID BE!!!

A Welsh company named LOMOX Ltd. has been working on creating OLED Wallpaper that could very well eliminate standard lighting. LOMOX Ltd”s organic light emitting diode technology (OLED), will be able to provide lighting solutions to homes, businesses and even roadways. The light is provided by chemicals that are applied on a surface to which are capable of emitting a natural looking light and only require between three to five volts to run, making it more then twice as efficient than current energy saving light bulbs.

””This is a chemical that in a flat panel display screen you can put it in the device and it emits light. You can put it anywhere, even paint it on a wall or wallpaper.””
-Ken Lacey, Chief Executive of LOMOX Ltd

Due to its flexibility, OLED”s have potential for numerous applications; televisions, computers, mobile phones, walls and even road signs. This ground breaking technology could also be used to make flexible screens that could be rolled up after use, and would also provide an effective alternative to outside lighting with traditional lights. Another benefit is that all of these applications can also be powered by greener alternatives such as solar energy. LOMOX Ltd. hopes to roll out the first applications for outdoor signage and displays as early as 2012.